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Target
UDP-N-acetylenolpyruvoylglucosamine reductase
Ligand
BDBM50166493
Substrate
n/a
Meas. Tech.
ChEMBL_304867 (CHEMBL829244)
IC50
5100±n/a nM
Citation
 Kutterer, KM; Davis, JM; Singh, G; Yang, Y; Hu, W; Severin, A; Rasmussen, BA; Krishnamurthy, G; Failli, A; Katz, AH 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett 15:2527-31 (2005) [PubMed]  Article 
Target
Name:
UDP-N-acetylenolpyruvoylglucosamine reductase
Synonyms:
MURB_STAAU | MurB (S. aureus) | UDP-N-acetylenolpyruvoylglucosamine reductase | murB
Type:
Protein
Mol. Mass.:
33791.48
Organism:
Staphylococcus aureus (Firmicutes)
Description:
S. aureus MurB
Residue:
307
Sequence:
MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSIIQKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGEHPKES
  
Inhibitor
Name:
BDBM50166493
Synonyms:
4-(2-Benzylsulfanyl-ethyl)-1,2-bis-(4-chloro-phenyl)-pyrazolidine-3,5-dione | CHEMBL365364
Type:
Small organic molecule
Emp. Form.:
C24H20Cl2N2O2S
Mol. Mass.:
471.399
SMILES:
Oc1c(CCSCc2ccccc2)c(=O)n(-c2ccc(Cl)cc2)n1-c1ccc(Cl)cc1
Structure:
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