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Target
Tryptase beta-2
Ligand
BDBM50167531
Substrate
n/a
Meas. Tech.
ChEMBL_302629 (CHEMBL839921)
Ki
41±n/a nM
Citation
 Hopkins, CR; Czekaj, M; Kaye, SS; Gao, Z; Pribish, J; Pauls, H; Liang, G; Sides, K; Cramer, D; Cairns, J; Luo, Y; Lim, HK; Vaz, R; Rebello, S; Maignan, S; Dupuy, A; Mathieu, M; Levell, J Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase. Bioorg Med Chem Lett 15:2734-7 (2005) [PubMed]  Article 
Target
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Inhibitor
Name:
BDBM50167531
Synonyms:
CHEMBL365527 | [4-(3-Aminomethyl-phenyl)-piperidin-1-yl]-(7-methyl-1-propyl-1H-indol-3-yl)-methanone; TFA
Type:
Small organic molecule
Emp. Form.:
C25H31N3O
Mol. Mass.:
389.5331
SMILES:
CCCn1cc(C(=O)N2CCC(CC2)c2cccc(CN)c2)c2cccc(C)c12
Structure:
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