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Target
ADP-ribose glycohydrolase MACROD2
Ligand
BDBM50595207
Substrate
n/a
Meas. Tech.
ChEMBL_2215848 (CHEMBL5128980)
IC50
>300000±n/a nM
Citation
 Sherrill, LM; Joya, EE; Walker, A; Roy, A; Alhammad, YM; Atobatele, M; Wazir, S; Abbas, G; Keane, P; Zhuo, J; Leung, AKL; Johnson, DK; Lehtiö, L; Fehr, AR; Ferraris, D Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain. Bioorg Med Chem 67:0 (2022) [PubMed] 
Target
Name:
ADP-ribose glycohydrolase MACROD2
Synonyms:
3.2.2.- | 3.5.1.- | ADP-ribose glycohydrolase MACROD2 | C20orf133 | MACD2_HUMAN | MACRO domain-containing protein 2 | MACROD2 | O-acetyl-ADP-ribose deacetylase MACROD2 | [Protein ADP-ribosylaspartate] hydrolase MACROD2 | [Protein ADP-ribosylglutamate] hydrolase MACROD2
Type:
PROTEIN
Mol. Mass.:
47383.93
Organism:
Homo sapiens
Description:
ChEMBL_117875
Residue:
425
Sequence:
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRNGTK
  
Inhibitor
Name:
BDBM50595207
Synonyms:
CHEMBL5208626
Type:
Small organic molecule
Emp. Form.:
C12H14N4O2
Mol. Mass.:
246.2652
SMILES:
OC(=O)C1CCCN(C1)c1ncnc2[nH]ccc12
Structure:
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