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Target
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Ligand
BDBM50597430
Substrate
n/a
Meas. Tech.
ChEMBL_2223430 (CHEMBL5136764)
IC50
>30000±n/a nM
Citation
 Hill, MD; Blanco, MJ; Salituro, FG; Bai, Z; Beckley, JT; Ackley, MA; Dai, J; Doherty, JJ; Harrison, BL; Hoffmann, EC; Kazdoba, TM; Lanzetta, D; Lewis, M; Quirk, MC; Robichaud, AJ SAGE-718: A First-in-Class  J Med Chem 65:9063-9075 (2022) [PubMed] 
Target
Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Synonyms:
BCNG-2 | BCNG2 | Brain cyclic nucleotide-gated channel 2 | HCN2 | HCN2_HUMAN
Type:
PROTEIN
Mol. Mass.:
96973.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_767273
Residue:
889
Sequence:
MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRPASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSARSRLSSNL
  
Inhibitor
Name:
BDBM50597430
Synonyms:
DALZANEMDOR | Dalzanemdor
Type:
Small organic molecule
Emp. Form.:
C27H43F3O2
Mol. Mass.:
456.6243
SMILES:
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@](C)(O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CC[C@](C)(O)C(F)(F)F |r,t:9|
Structure:
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