Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50174876
Substrate
n/a
Meas. Tech.
ChEMBL_326975 (CHEMBL868738)
EC50
3±n/a nM
Citation
 Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett 15:5504-8 (2005) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50174876
Synonyms:
CHEMBL383143 | X1-Apc-DPhe-Arg-Trp-Z3-NH2
Type:
Small organic molecule
Emp. Form.:
C46H60N10O6
Mol. Mass.:
849.032
SMILES:
CCCC(=O)N[C@@]1(CC[C@@H](CC1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(N)=O |wU:32.34,9.12,21.22,6.5,57.62,wD:6.19,43.45,(-6.2,-41.29,;-4.87,-40.52,;-3.54,-41.29,;-2.21,-40.52,;-2.21,-38.98,;-.87,-41.29,;.48,-40.52,;1.81,-39.76,;1.81,-38.23,;.48,-37.45,;-.86,-38.21,;-.86,-39.76,;.49,-35.92,;1.82,-35.15,;1.83,-33.63,;.5,-32.85,;-.84,-33.62,;-.84,-35.15,;1.8,-41.29,;1.8,-42.83,;3.14,-40.52,;4.48,-41.29,;4.48,-42.83,;5.81,-43.61,;5.8,-45.15,;7.14,-45.92,;8.48,-45.15,;8.47,-43.6,;7.13,-42.84,;5.81,-40.52,;5.81,-38.98,;7.15,-41.29,;8.48,-40.52,;8.48,-38.98,;9.82,-38.2,;9.82,-36.66,;11.16,-35.89,;11.16,-34.35,;12.5,-33.57,;9.82,-33.57,;9.82,-41.29,;9.82,-42.83,;11.16,-40.52,;12.5,-41.29,;12.5,-42.83,;13.84,-43.61,;15.18,-42.82,;16.29,-44.12,;15.51,-45.46,;15.98,-46.92,;14.96,-48.06,;13.44,-47.75,;12.97,-46.28,;14.01,-45.13,;13.84,-40.52,;13.84,-38.98,;15.18,-41.29,;16.5,-40.52,;16.5,-38.98,;17.84,-41.28,;19.17,-40.51,;17.83,-42.82,)|
Structure:
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