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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM13465
Substrate
n/a
Meas. Tech.
ChEMBL_321250 (CHEMBL881785)
IC50
135±n/a nM
Citation
 Combs, AP; Yue, EW; Bower, M; Ala, PJ; Wayland, B; Douty, B; Takvorian, A; Polam, P; Wasserman, Z; Zhu, W; Crawley, ML; Pruitt, J; Sparks, R; Glass, B; Modi, D; McLaughlin, E; Bostrom, L; Li, M; Galya, L; Blom, K; Hillman, M; Gonneville, L; Reid, BG; Wei, M; Becker-Pasha, M; Klabe, R; Huber, R; Li, Y; Hollis, G; Burn, TC; Wynn, R; Liu, P; Metcalf, B Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics. J Med Chem 48:6544-8 (2005) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM13465
Synonyms:
(2S)-N-[(1S)-1-carbamoyl-2-{4-[(5S)-1,1,3-trioxo-1,2-thiazolidin-5-yl]phenyl}ethyl]-2-acetamido-3-phenylpropanamide | CHEMBL382311 | IZD 8 | Isothiazolidinone (IZD) deriv. 6 | Saturated (S)-IZD
Type:
Small organic molecule
Emp. Form.:
C23H26N4O6S
Mol. Mass.:
486.541
SMILES:
CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(cc1)[C@@H]1CC(=O)NS1(=O)=O)C(N)=O |r|
Structure:
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