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Target
Serine/threonine-protein kinase 4
Ligand
BDBM50599308
Substrate
n/a
Meas. Tech.
ChEMBL_2229524 (CHEMBL5143037)
IC50
60±n/a nM
Citation
 Wu, Y; Qi, Z; Wang, B; Wang, J; Liu, Q; Wang, A; Shi, C; Zhou, B; Liang, Q; Wang, W; Zou, F; Qi, S; Wang, Z; Wang, L; Wang, W; Liu, J; Liu, Q Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes. J Med Chem 65:11818-11839 (2022) [PubMed] 
Target
Name:
Serine/threonine-protein kinase 4
Synonyms:
KRS2 | MST1 | STK4 | STK4_HUMAN | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase 4 (STK4) | Serine/threonine-protein kinase MST1
Type:
Enzyme
Mol. Mass.:
55611.40
Organism:
Homo sapiens (Human)
Description:
Q13043
Residue:
487
Sequence:
METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
  
Inhibitor
Name:
BDBM50599308
Synonyms:
CHEMBL5200426
Type:
Small organic molecule
Emp. Form.:
C25H28N6O3S
Mol. Mass.:
492.593
SMILES:
CN1C(C(=O)N(C)c2cnc(Nc3ccc(cc3)S(=O)(=O)NCC3CC3)nc12)c1ccccc1C
Structure:
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