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Target
Histamine H3 receptor
Ligand
BDBM50177731
Substrate
n/a
Meas. Tech.
ChEMBL_334743 (CHEMBL854129)
Ki
0.5±n/a nM
Citation
 Swanson, DM; Wilson, SJ; Boggs, JD; Xiao, W; Apodaca, R; Barbier, AJ; Lovenberg, TW; Carruthers, NI Aplysamine-1 and related analogs as histamine H3 receptor antagonists. Bioorg Med Chem Lett 16:897-900 (2006) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50177731
Synonyms:
CHEMBL204872 | dimethyl-{2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-ethyl}-amine
Type:
Small organic molecule
Emp. Form.:
C18H30N2O
Mol. Mass.:
290.4436
SMILES:
CN(C)CCc1ccc(OCCCN2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: