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Target
Interleukin-1 receptor antagonist protein
Ligand
BDBM50601042
Substrate
n/a
Meas. Tech.
ChEMBL_2235735 (CHEMBL5149507)
IC50
19±n/a nM
Citation
 Vourloumis, D; Mavridis, I; Athanasoulis, A; Temponeras, I; Koumantou, D; Giastas, P; Mpakali, A; Magrioti, V; Leib, J; van Endert, P; Stratikos, E; Papakyriakou, A Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on ?-Hydroxy-?-amino Acid Derivatives of Bestatin. J Med Chem 65:10098-10117 (2022) [PubMed] 
Target
Name:
Interleukin-1 receptor antagonist protein
Synonyms:
ICIL-1RA | IL-1RN | IL-1ra | IL1 inhibitor | IL1F3 | IL1RA | IL1RA_HUMAN | IL1RN | INN=Anakinra | IRAP | Interleukin-1 receptor antagonist protein
Type:
PROTEIN
Mol. Mass.:
20053.78
Organism:
Homo sapiens
Description:
ChEMBL_118941
Residue:
177
Sequence:
MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
  
Inhibitor
Name:
BDBM50601042
Synonyms:
CHEMBL5195885
Type:
Small organic molecule
Emp. Form.:
C28H33F3N4O6
Mol. Mass.:
578.58
SMILES:
COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)COc1cc(F)c(F)c(F)c1 |r|
Structure:
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