Reaction Details Report a problem with these data
Target
Phospholipase A2, major isoenzyme
Ligand
BDBM50055384
Substrate
n/a
Meas. Tech.
ChEMBL_2237082 (CHEMBL5150978)
IC50
7.0±n/a nM
Citation
 Robello, M; Barresi, E; Baglini, E; Salerno, S; Taliani, S; Settimo, FD The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities. J Med Chem 64:3508-3545 (2021) [PubMed] 
Target
Name:
Phospholipase A2, major isoenzyme
Synonyms:
Group IB phospholipase A2 | PA21B_PIG | PLA2G1B | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2
Type:
Hydrolase; monomer or homodimer
Mol. Mass.:
16279.83
Organism:
Sus scrofa (pig)
Description:
Purchased from Sigma.
Residue:
146
Sequence:
MKFLVLAVLLTVGAAQEGISSRALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPVDELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYC
  
Inhibitor
Name:
BDBM50055384
Synonyms:
(3-Aminooxalyl-1-biphenyl-3-ylmethyl-2-methyl-1H-indol-4-yloxy)-acetic acid | CHEMBL355944
Type:
Small organic molecule
Emp. Form.:
C26H22N2O5
Mol. Mass.:
442.4633
SMILES:
Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1cccc(c1)-c1ccccc1
Structure:
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