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Found 133 with Last Name = 'settimo' and Initial = 'fd'
TargetTranslocator protein(Bos taurus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50019213(1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity to bovine brain membrane BzR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTranslocator protein(Bos taurus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to bovine brain membrane BzR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin K(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601464(CHEMBL5195850)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human Cathepsin K assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Niddk

Curated by ChEMBL
LigandPNGBDBM50143225(CHEMBL300762 | N,N-Dibutyl-2-[5-chloro-2-(4-chloro...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120763(CHEMBL358076 | Cyclopentanecarboxylic acid (7-ethy...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120761(CHEMBL355898 | Cyclopentanecarboxylic acid (7-meth...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601465(CHEMBL5204536)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Niddk

Curated by ChEMBL
LigandPNGBDBM50143238(2-[5-Chloro-2-(4-chloro-phenyl)-1H-indol-3-yl]-N,N...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120767(CHEMBL148464 | Cyclopentanecarboxylic acid (7-isop...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Niddk

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50120759(CHEMBL146479 | N-(7-Methyl-2-phenyl-imidazo[1,2-a]...)
Affinity DataKi:  11.8nMAssay Description:Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120765(1-(7-Methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50101427((R)-2-(5-nitro-1H-indol-3-yl)-2-oxo-N-(1-phenyleth...)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha1-beta2-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50101429(2-(1H-Indol-3-yl)-N-(4-nitro-benzyl)-2-oxo-acetami...)
Affinity DataKi:  16nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha1-beta2-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120764(CHEMBL149732 | Cyclopentanecarboxylic acid (2,7-di...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50120767(CHEMBL148464 | Cyclopentanecarboxylic acid (7-isop...)
Affinity DataKi:  17.4nMAssay Description:Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50258312(CHEMBL4095528)
Affinity DataKi:  18nMAssay Description:Inhibition of Calpain I (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50120763(CHEMBL358076 | Cyclopentanecarboxylic acid (7-ethy...)
Affinity DataKi:  20.2nMAssay Description:Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Niddk

Curated by ChEMBL
LigandPNGBDBM22040(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)
Affinity DataKi:  23nMAssay Description:Binding affinity rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120766(CHEMBL147582 | N-(2,7-Diphenyl-imidazo[1,2-a][1,3,...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50066949((1H-Indol-3-yl)-oxo-acetic acid N'-(4-nitro-phenyl...)
Affinity DataKi:  25nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha1-beta2-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120759(CHEMBL146479 | N-(7-Methyl-2-phenyl-imidazo[1,2-a]...)
Affinity DataKi:  27.2nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601464(CHEMBL5195850)
Affinity DataKi:  28nMAssay Description:Inhibition of human Cathepsin B assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50258383(CHEMBL4063636)
Affinity DataKi:  34nMAssay Description:Inhibition of Calpain I (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50066949((1H-Indol-3-yl)-oxo-acetic acid N'-(4-nitro-phenyl...)
Affinity DataKi:  40nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha3-beta2-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50120766(CHEMBL147582 | N-(2,7-Diphenyl-imidazo[1,2-a][1,3,...)
Affinity DataKi:  40nMAssay Description:Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120758(CHEMBL148074 | Cyclopentyl-(7-methyl-2-phenyl-imid...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50055247(CHEMBL75306 | N-(4-Methoxy-benzyl)-2-(5-nitro-1H-i...)
Affinity DataKi:  42nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha1-beta2-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50066949((1H-Indol-3-yl)-oxo-acetic acid N'-(4-nitro-phenyl...)
Affinity DataKi:  43nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha5-beta3-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Affinity DataKi:  50nMAssay Description:Inhibition of [3H]-flumazenil specific binding at rat GABA-A alpha1-beta2-gamma2 receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601464(CHEMBL5195850)
Affinity DataKi:  56nMAssay Description:Inhibition of human Calpain I assessed as dissociation constant using Suc-Leu-Tyr-AMC as substrate preincubated for 15 mins followed by compound addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50101429(2-(1H-Indol-3-yl)-N-(4-nitro-benzyl)-2-oxo-acetami...)
Affinity DataKi:  58nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha5-beta3-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50268784((R)-N-(2,3-dihydro-1H-inden-1-yl)-2-(5-nitro-1H-in...)
Affinity DataKi:  95nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha5-beta3-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601468(CHEMBL5179024)
Affinity DataKi:  108nMAssay Description:Displacement of [3H] PK11195 from TSPO in human U-87 MGcell membrane assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120760(CHEMBL343256 | Cyclohexanecarboxylic acid (7-methy...)
Affinity DataKi:  116nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Bos taurus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055261(CHEMBL75307 | N-Benzyl-2-(5-nitro-1H-indol-3-yl)-2...)
Affinity DataKi:  117nMAssay Description:Binding affinity to bovine brain membrane BzR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50055247(CHEMBL75306 | N-(4-Methoxy-benzyl)-2-(5-nitro-1H-i...)
Affinity DataKi:  126nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha5-beta3-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601464(CHEMBL5195850)
Affinity DataKi:  137nMAssay Description:Inhibition of human Cathepsin L assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50055247(CHEMBL75306 | N-(4-Methoxy-benzyl)-2-(5-nitro-1H-i...)
Affinity DataKi:  137nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha3-beta2-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601467(CHEMBL5169788)
Affinity DataKi:  202nMAssay Description:Displacement of [3H] PK11195 from TSPO (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50120760(CHEMBL343256 | Cyclohexanecarboxylic acid (7-methy...)
Affinity DataKi:  202nMAssay Description:Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50089770(1-(1,3-Dihydro-isoindol-2-yl)-2-(1H-indol-3-yl)-et...)
Affinity DataKi:  224nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha1-beta2-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50120753(CHEMBL421782 | N-(7-Methyl-2-phenyl-imidazo[1,2-a]...)
Affinity DataKi:  231nMAssay Description:Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120754(CHEMBL147913 | Cyclohexylmethyl-(7-methyl-2-phenyl...)
Affinity DataKi:  231nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50101427((R)-2-(5-nitro-1H-indol-3-yl)-2-oxo-N-(1-phenyleth...)
Affinity DataKi:  239nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha5-beta3-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50101427((R)-2-(5-nitro-1H-indol-3-yl)-2-oxo-N-(1-phenyleth...)
Affinity DataKi:  283nMAssay Description:Inhibition of [3H]-flumazenil binding to rat alpha3-beta2-gamma2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120757(7-Methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-4-y...)
Affinity DataKi:  332nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50120761(CHEMBL355898 | Cyclopentanecarboxylic acid (7-meth...)
Affinity DataKi:  410nMAssay Description:Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601466(CHEMBL5172740)
Affinity DataKi:  438nMAssay Description:Displacement of [3H] PK11195 from TSPO (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenosine receptor A1(BOVINE)
Università

Curated by ChEMBL
LigandPNGBDBM50120770(Adamantan-1-yl-(7-methyl-2-phenyl-imidazo[1,2-a][1...)
Affinity DataKi:  511nMAssay Description:Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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