Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50601572
Substrate
n/a
Meas. Tech.
ChEMBL_2237560 (CHEMBL5151456)
Ki
6.2±n/a nM
Citation
 Tropmann, K; Bresinsky, M; Forster, L; Mönnich, D; Buschauer, A; Wittmann, HJ; Hübner, H; Gmeiner, P; Pockes, S; Strasser, A Abolishing Dopamine D J Med Chem 64:8684-8709 (2021) [PubMed] 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50601572
Synonyms:
CHEMBL5208722
Type:
Small organic molecule
Emp. Form.:
C20H24F6N6O5
Mol. Mass.:
542.4322
SMILES:
OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.C[C@@H](NC(=O)\N=C(/N)NCCCc1c[nH]cn1)c1ccccc1 |r|
Structure:
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