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Target
Genome polyprotein
Ligand
BDBM50478971
Substrate
n/a
Meas. Tech.
ChEMBL_2237924 (CHEMBL5151820)
IC50
5260±n/a nM
Citation
 Nascimento, IJDS; Santos-Júnior, PFDS; Aquino, TM; Araújo-Júnior, JX; Silva-Júnior, EFD Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors. Eur J Med Chem 224:0 (2021) [PubMed] 
Target
Name:
Genome polyprotein
Synonyms:
NS5
Type:
PROTEIN
Mol. Mass.:
39098.80
Organism:
Zika virus
Description:
ChEMBL_119669
Residue:
340
Sequence:
EFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVEGLGLQRLGYVLEEMSRIPGGRMYADDTAGWDTRISRFDLENEALITNQMEKGHRALALAIIKYTYQNKVVKVLRPAEKGKTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRRSEKVTNWLQSNGWDRLKRMAVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWDNWEEVPFCSHHFNKLHLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKSYAQMWQLLYFHRRDLRLMANAICSSVPVDWVPTGRTTWSIHGKGE
  
Inhibitor
Name:
BDBM50478971
Synonyms:
2''C-Me-ATP | CHEMBL374931
Type:
Small organic molecule
Emp. Form.:
C11H18N5O13P3
Mol. Mass.:
521.2076
SMILES:
C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1cnc2c(N)ncnc12 |r|
Structure:
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