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Target
Enoyl-acyl-carrier protein reductase
Ligand
BDBM50182391
Substrate
n/a
Meas. Tech.
ChEMBL_347035 (CHEMBL866856)
IC50
22000±n/a nM
Citation
 Freundlich, JS; Yu, M; Lucumi, E; Kuo, M; Tsai, HC; Valderramos, JC; Karagyozov, L; Jacobs, WR; Schiehser, GA; Fidock, DA; Jacobus, DP; Sacchettini, JC Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives. Bioorg Med Chem Lett 16:2163-9 (2006) [PubMed]  Article 
Target
Name:
Enoyl-acyl-carrier protein reductase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
49770.86
Organism:
Plasmodium falciparum
Description:
ChEMBL_795989
Residue:
432
Sequence:
MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNKMKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYPIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKNSASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRNENE
  
Inhibitor
Name:
BDBM50182391
Synonyms:
2-(2-(((4-chlorobenzyl)(methyl)amino)methyl)-4-chlorophenoxy)-5-chlorophenol | CHEMBL208218
Type:
Small organic molecule
Emp. Form.:
C21H18Cl3NO2
Mol. Mass.:
422.732
SMILES:
CN(Cc1ccc(Cl)cc1)Cc1cc(Cl)ccc1Oc1ccc(Cl)cc1O
Structure:
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