Reaction Details Report a problem with these data
Target
Aryl hydrocarbon receptor
Ligand
BDBM50602335
Substrate
n/a
Meas. Tech.
ChEMBL_2240102 (CHEMBL5153998)
EC50
0.058±n/a nM
Citation
 Flegel, J; Shaaban, S; Jia, ZJ; Schulte, B; Lian, Y; Krzyzanowski, A; Metz, M; Schneidewind, T; Wesseler, F; Flegel, A; Reich, A; Brause, A; Xue, G; Zhang, M; Dötsch, L; Stender, ID; Hoffmann, JE; Scheel, R; Janning, P; Rastinejad, F; Schade, D; Strohmann, C; Antonchick, AP; Sievers, S; Moura-Alves, P; Ziegler, S; Waldmann, H The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation. J Med Chem 65:16268-16289 (2022) [PubMed] 
Target
Name:
Aryl hydrocarbon receptor
Synonyms:
AHR_MOUSE | Ah Receptor | Ahr | Aryl hydrocarbon receptor
Type:
Protein
Mol. Mass.:
95014.92
Organism:
Mus musculus (Mouse)
Description:
P30561
Residue:
848
Sequence:
MSSGANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRNGGQDQCRAQIRDWQDLQEGEFLLQALNGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPDSAQGVDEAHGPPQAAVYYTPDQLPPENASFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCTRGSGYQFIHAADMLHCAESHIRMIKTGESGMTVFRLFAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDEEGREHLQKRSTSLPFMFATGEAVLYEISSPFSPIMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPSSLMSALIQQDESIYLCPPSSPAPLDSHFLMGSVSKCGSWQDSFAAAGSEAALKHEQIGHAQDVNLALSGGPSELFPDNKNNDLYNIMRNLGIDFEDIRSMQNEEFFRTDSTAAGEVDFKDIDITDEILTYVQDSLNNSTLMNSACQQQPVTQHLSCMLQERLQLEQQQQLQQPPPQALEPQQQLCQMVCPQQDLGPKHTQINGTFASWNPTPPVSFNCPQQELKHYQLFSSLQGTAQEFPYKPEVDSVPYTQNFAPCNQPLLPEHSKSVQLDFPGRDFEPSLHPTTSNLDFVSCLQVPENQSHGINSQSTMVSPQAYYAGAMSMYQCQPGPQRTPVDQTQYSSEIPGSQAFLSKVQSRGIFNETYSSDLSSIGHAAQTTGHLHHLAEARPLPDITPGGFL
  
Inhibitor
Name:
BDBM50602335
Synonyms:
CHEMBL5186309
Type:
Small organic molecule
Emp. Form.:
C17H13BrClNO
Mol. Mass.:
362.648
SMILES:
[H][C@@]12Cc3cc(Cl)c(Br)cc3C(=O)N1CCc1ccccc21 |r|
Structure:
Search PDB for entries with ligand similarity: