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Target
C-C chemokine receptor type 4
Ligand
BDBM50183092
Substrate
n/a
Meas. Tech.
ChEMBL_350559 (CHEMBL870148)
IC50
12100±n/a nM
Citation
 Wang, X; Xu, F; Xu, Q; Mahmud, H; Houze, J; Zhu, L; Akerman, M; Tonn, G; Tang, L; McMaster, BE; Dairaghi, DJ; Schall, TJ; Collins, TL; Medina, JC Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett 16:2800-3 (2006) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM50183092
Synonyms:
3-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)amino)methyl)-N-(2,3-dimethylphenyl)isoxazol-5-amine | CHEMBL206921
Type:
Small organic molecule
Emp. Form.:
C27H32F3N3O
Mol. Mass.:
471.5577
SMILES:
Cc1cccc(Nc2cc(CN(CC3CCCCC3)Cc3ccccc3C(F)(F)F)no2)c1C
Structure:
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