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Target
C-C chemokine receptor type 4
Ligand
BDBM50183119
Substrate
n/a
Meas. Tech.
ChEMBL_350559 (CHEMBL870148)
IC50
14±n/a nM
Citation
 Wang, X; Xu, F; Xu, Q; Mahmud, H; Houze, J; Zhu, L; Akerman, M; Tonn, G; Tang, L; McMaster, BE; Dairaghi, DJ; Schall, TJ; Collins, TL; Medina, JC Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett 16:2800-3 (2006) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM50183119
Synonyms:
4-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)amino)methyl)-N-(naphthalen-1-yl)thiazol-2-amine | CHEMBL377421
Type:
Small organic molecule
Emp. Form.:
C29H30F3N3S
Mol. Mass.:
509.629
SMILES:
FC(F)(F)c1ccccc1CN(CC1CCCCC1)Cc1csc(Nc2cccc3ccccc23)n1
Structure:
Search PDB for entries with ligand similarity: