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Target
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Ligand
BDBM50183258
Substrate
n/a
Meas. Tech.
ChEMBL_354992 (CHEMBL870123)
Ki
1.7±n/a nM
Citation
 Kamath, VP; Zhang, J; Morris, PE; Babu, YS Synthesis of a potent 5'-methylthioadenosine/S-adenosylhomocysteine (MTAN) inhibitor. Bioorg Med Chem Lett 16:2662-5 (2006) [PubMed]  Article 
Target
Name:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Synonyms:
5 -methylthioadenosine nucleosidase | 5'-methylthioadenosine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) | MTA/SAH nucleosidase | MTAN | MTNN_ECOLI | Methylthioadenosine Nucleosidase(MTAN) | P46 | S-adenosylhomocysteine nucleosidase | mtn | mtnN | pfs | yadA
Type:
Enzyme
Mol. Mass.:
24347.14
Organism:
Escherichia coli (strain K12)
Description:
P0AF12
Residue:
232
Sequence:
MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
  
Inhibitor
Name:
BDBM50183258
Synonyms:
2-amino-4-[5-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxypyrrolidin-2-ylmethylsulfanyl]-butyric acid | CHEMBL207655
Type:
Small organic molecule
Emp. Form.:
C15H22N6O4S
Mol. Mass.:
382.438
SMILES:
NC(CCSC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c(N)ncnc12)C(O)=O
Structure:
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