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Target
Cathepsin L2
Ligand
BDBM50033762
Substrate
n/a
Meas. Tech.
ChEMBL_2241117 (CHEMBL5155327)
IC50
697±n/a nM
Citation
 Ashhurst, AS; Tang, AH; Fajtová, P; Yoon, MC; Aggarwal, A; Bedding, MJ; Stoye, A; Beretta, L; Pwee, D; Drelich, A; Skinner, D; Li, L; Meek, TD; McKerrow, JH; Hook, V; Tseng, CT; Larance, M; Turville, S; Gerwick, WH; O'Donoghue, AJ; Payne, RJ Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. J Med Chem 65:2956-2970 (2022) [PubMed] 
Target
Name:
Cathepsin L2
Synonyms:
CATL2 | CATL2_HUMAN | CTSL2 | CTSU | CTSV | Cathepsin U | Cathepsin V
Type:
Enzyme
Mol. Mass.:
37341.06
Organism:
Homo sapiens (Human)
Description:
O60911
Residue:
334
Sequence:
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
  
Inhibitor
Name:
BDBM50033762
Synonyms:
Gallinamide A
Type:
Small organic molecule
Emp. Form.:
C31H52N4O7
Mol. Mass.:
592.7672
SMILES:
CC[C@H](C)[C@H](N(C)C)C(=O)O[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)\C=C\C(=O)N1[C@@H](C)C(OC)=CC1=O |r,c:38|
Structure:
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