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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM23163
Substrate
n/a
Meas. Tech.
ChEMBL_2243774 (CHEMBL5157984)
EC50
1.7±n/a nM
Citation
 Park, SJ; Yeon, SK; Kim, Y; Kim, HJ; Kim, S; Kim, J; Choi, JW; Kim, B; Lee, EH; Kim, R; Seo, SH; Lee, J; Kim, JW; Lee, HY; Hwang, H; Bahn, YS; Cheong, E; Park, JH; Park, KD Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis. J Med Chem 65:3539-3562 (2022) [PubMed] 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM23163
Synonyms:
CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy}phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C19H34NO5P
Mol. Mass.:
387.4507
SMILES:
CCCCCCCCc1ccc(CCC(N)(CO)COP(O)(O)=O)cc1
Structure:
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