Affinity DataKi: 627nMAssay Description:Displacement of [3H]furoyl-LIGRL-NH2 from human protease-activated receptor 2 in NCTC-2544 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.60E+3nMAssay Description:Mixed type inhibition of recombinant human BACE1 using Rh-EVNLDAEFK-Quencher as substrate after 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.94E+3nMAssay Description:Displacement of [3H]furoyl-LIGRL-NH2 from human protease-activated receptor 2 in NCTC-2544 cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Catholic University of Daegu
Catholic University of Daegu
Affinity DataKi: 2.60E+3nMAssay Description:The reaction mixtures contained in various different concentrations of p-NPP as a PTP1B substrate in the presence or absence of the active compound. ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Catholic University of Daegu
Catholic University of Daegu
Affinity DataKi: 2.80E+3nMAssay Description:The reaction mixtures contained in various different concentrations of p-NPP as a PTP1B substrate in the presence or absence of the active compound. ...More data for this Ligand-Target Pair
Affinity DataKi: 2.90E+3nMAssay Description:Noncompetitive inhibition of recombinant human BACE1 using Rh-EVNLDAEFK-Quencher as substrate after 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Catholic University of Daegu
Catholic University of Daegu
Affinity DataKi: 3.00E+3nM ΔG°: -32.8kJ/mole IC50: 4.80E+3nMpH: 6.0 T: 2°CAssay Description:In each 96-well plates (total 200 μL of volume), there were 2 mM p-NPP and PTP1B (0.05-0.1 μg) in a buffer containing 50 mM citrate (pH 6.0...More data for this Ligand-Target Pair
Affinity DataKi: 4.00E+3nMAssay Description:Mixed type inhibition of recombinant human BACE1 using Rh-EVNLDAEFK-Quencher as substrate after 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Catholic University of Daegu
Catholic University of Daegu
Affinity DataKi: 9.70E+3nM ΔG°: -29.8kJ/mole IC50: 1.38E+4nMpH: 6.0 T: 2°CAssay Description:In each 96-well plates (total 200 μL of volume), there were 2 mM p-NPP and PTP1B (0.05-0.1 μg) in a buffer containing 50 mM citrate (pH 6.0...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Catholic University of Daegu
Catholic University of Daegu
Affinity DataKi: 1.11E+4nM ΔG°: -29.4kJ/mole IC50: 1.46E+4nMpH: 6.0 T: 2°CAssay Description:In each 96-well plates (total 200 μL of volume), there were 2 mM p-NPP and PTP1B (0.05-0.1 μg) in a buffer containing 50 mM citrate (pH 6.0...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Catholic University of Daegu
Catholic University of Daegu
Affinity DataKi: 1.13E+4nM ΔG°: -29.4kJ/mole IC50: 1.45E+4nMpH: 6.0 T: 2°CAssay Description:In each 96-well plates (total 200 μL of volume), there were 2 mM p-NPP and PTP1B (0.05-0.1 μg) in a buffer containing 50 mM citrate (pH 6.0...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Catholic University of Daegu
Catholic University of Daegu
Affinity DataKi: 1.39E+4nM ΔG°: -28.8kJ/mole IC50: 1.59E+4nMpH: 6.0 T: 2°CAssay Description:In each 96-well plates (total 200 μL of volume), there were 2 mM p-NPP and PTP1B (0.05-0.1 μg) in a buffer containing 50 mM citrate (pH 6.0...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Catholic University of Daegu
Catholic University of Daegu
Affinity DataKi: 1.45E+4nM ΔG°: -28.7kJ/mole IC50: 1.32E+4nMpH: 6.0 T: 2°CAssay Description:In each 96-well plates (total 200 μL of volume), there were 2 mM p-NPP and PTP1B (0.05-0.1 μg) in a buffer containing 50 mM citrate (pH 6.0...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cellsMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cellsMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cellsMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cellsMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of FMS (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of c-Src (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human ERG assessed as reduction in channel current by automated patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of wild type BCR-ABL (unknown origin) incubated for 40 mins in presence of [gamma33P]ATP by scintillation methodMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cellsMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human C-RAF measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...More data for this Ligand-Target Pair
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against Escherichia coli Methionyl-tRNA synthetase was determinedMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of BRAF (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibitory activity against Escherichia coli Isoleucyl-tRNA synthetase was determinedMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human C-RAF measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of wild type BCR-ABL (unknown origin) incubated for 40 mins in presence of [gamma33P]ATP by scintillation methodMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of FMS (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of wild type BCR-ABL (unknown origin) incubated for 40 mins in presence of [gamma33P]ATP by scintillation methodMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Cells of Chem3 Cell Line (HTS145C:Millipore) in which mGluR1 was stably expressed were adjusted to a density of 2×106/ml. 50 μl of the cells wer...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibitory activity against Escherichia coli Isoleucyl-tRNA synthetase was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...More data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of BCR-ABL T315I mutant (unknown origin) incubated for 40 mins in presence of [gamma33P]ATP by scintillation methodMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Korea Institute Of Science And Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of wild type BCR-ABL (unknown origin) incubated for 40 mins in presence of [gamma33P]ATP by scintillation methodMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Cells of Chem3 Cell Line (HTS145C:Millipore) in which mGluR1 was stably expressed were adjusted to a density of 2×106/ml. 50 μl of the cells wer...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...More data for this Ligand-Target Pair