Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50186123
Substrate
n/a
Meas. Tech.
ChEMBL_371315 (CHEMBL865536)
Ki
326±n/a nM
Citation
Briner, K; Collado, I; Fisher, MJ; García-Paredes, C; Husain, S; Kuklish, SL; Mateo, AI; O'Brien, TP; Ornstein, PL; Zgombick, J; de Frutos, O Privileged structure based ligands for melanocortin-4 receptors--aliphatic piperazine derivatives. Bioorg Med Chem Lett 16:3449-53 (2006) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Inhibitor
Name:
BDBM50186123
Synonyms:
CHEMBL378568 | N-((R)-3-(4-chlorophenyl)-1-(4-(1,3-dicyclohexylpropan-2-yl)piperazin-1-yl)-1-oxopropan-2-yl)-2-(indolin-2-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C38H53ClN4O2
Mol. Mass.:
633.306
SMILES:
Clc1ccc(C[C@@H](NC(=O)CC2Cc3ccccc3N2)C(=O)N2CCN(CC2)C(CC2CCCCC2)CC2CCCCC2)cc1