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Target
Monoglyceride lipase
Ligand
BDBM50605682
Substrate
n/a
Meas. Tech.
ChEMBL_2252652 (CHEMBL5166862)
Ki
1.4±n/a nM
Citation
Bononi, G; Di Stefano, M; Poli, G; Ortore, G; Meier, P; Masetto, F; Caligiuri, I; Rizzolio, F; Macchia, M; Chicca, A; Avan, A; Giovannetti, E; Vagaggini, C; Brai, A; Dreassi, E; Valoti, M; Minutolo, F; Granchi, C; Gertsch, J; Tuccinardi, T Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives. J Med Chem 65:7118-7140 (2022) [PubMed]
More Info.:
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP