Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM50187800
Substrate
n/a
Meas. Tech.
ChEMBL_385593 (CHEMBL869126)
Ki
>150000±n/a nM
Citation
Sperandio, D; Tai, VW; Lohman, J; Hirschbein, B; Mendonca, R; Lee, CS; Spencer, JR; Janc, J; Nguyen, M; Beltman, J; Sprengeler, P; Scheerens, H; Lin, T; Liu, L; Gadre, A; Kellogg, A; Green, MJ; McGrath, ME Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors. Bioorg Med Chem Lett 16:4085-9 (2006) [PubMed] Article
More Info.:
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN