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Target
Lutropin-choriogonadotropic hormone receptor
Ligand
BDBM50189774
Substrate
n/a
Meas. Tech.
ChEMBL_367601 (CHEMBL864095)
EC50
1900±n/a nM
Citation
 Moore, S; Jaeschke, H; Kleinau, G; Neumann, S; Costanzi, S; Jiang, JK; Childress, J; Raaka, BM; Colson, A; Paschke, R; Krause, G; Thomas, CJ; Gershengorn, MC Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns. J Med Chem 49:3888-96 (2006) [PubMed]  Article 
Target
Name:
Lutropin-choriogonadotropic hormone receptor
Synonyms:
LCGR | LGR2 | LH/CG-R | LHCGR | LHR | LHRHR | LSH-R | LSHR_HUMAN | Luteinizing hormone receptor
Type:
PROTEIN
Mol. Mass.:
78662.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_562598
Residue:
699
Sequence:
MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
  
Inhibitor
Name:
BDBM50189774
Synonyms:
CHEMBL378091 | N-tert-butyl-5-amino-4-(3-hydroxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxamide
Type:
Small organic molecule
Emp. Form.:
C18H20N4O2S2
Mol. Mass.:
388.507
SMILES:
CSc1nc(-c2cccc(O)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Structure:
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