Reaction Details Report a problem with these data
Target
Low molecular weight phosphotyrosine protein phosphatase
Ligand
BDBM50607112
Substrate
n/a
Meas. Tech.
ChEMBL_2262140 (CHEMBL5217151)
IC50
36±n/a nM
Citation
 He, R; Wang, J; Yu, ZH; Moyers, JS; Michael, MD; Durham, TB; Cramer, JW; Qian, Y; Lin, A; Wu, L; Noinaj, N; Barrett, DG; Zhang, ZY Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. J Med Chem 65:13892-13909 (2022) [PubMed] 
Target
Name:
Low molecular weight phosphotyrosine protein phosphatase
Synonyms:
Acp1 | LMW-PTP | LMW-PTPase | Low molecular weight cytosolic acid phosphatase | Low molecular weight phosphotyrosine protein phosphatase | PPAC_MOUSE
Type:
PROTEIN
Mol. Mass.:
18192.04
Organism:
Mus musculus
Description:
ChEMBL_109834
Residue:
158
Sequence:
MAEVGSKSVLFVCLGNICRSPIAEAVFRKLVTDEKVSDNWRIDSAATSTYEVGNPPDYRGQNCMRKHGIHMQHIARQITKEDFATFDYILCMDESNLRDLNRKSNQVKNCKAKIELLGSYDPQKQLIIEDPYYGNDSDFEVVYQQCLRCCKAFLEKTY
  
Inhibitor
Name:
BDBM50607112
Synonyms:
CHEMBL5220114
Type:
Small organic molecule
Emp. Form.:
C12H15BrN2O5S
Mol. Mass.:
379.227
SMILES:
OS(=O)(=O)CC(=O)Nc1ccc(N2CCOCC2)c(Br)c1
Structure:
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