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Target
TYR_PHOSPHATASE_2 domain-containing protein
Ligand
BDBM50192335
Substrate
n/a
Meas. Tech.
ChEMBL_382598 (CHEMBL854513)
IC50
7300±n/a nM
Citation
 Müller, D; Krick, A; Kehraus, S; Mehner, C; Hart, M; Küpper, FC; Saxena, K; Prinz, H; Schwalbe, H; Janning, P; Waldmann, H; König, GM Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity. J Med Chem 49:4871-8 (2006) [PubMed]  Article 
Target
Name:
TYR_PHOSPHATASE_2 domain-containing protein
Synonyms:
(PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB
Type:
Hydrolase
Mol. Mass.:
30152.45
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
  
Inhibitor
Name:
BDBM50192335
Synonyms:
(2S,3S)-2-{3-[(3S,6S,9S,12S,15S)-3-benzyl-12-((S)-sec-butyl)-6-(1H-indol-3-ylmethyl)-9-isobutyl-7-methyl-2,5,8,11,14-pentaoxo-1,4,7,10,13pentaaza-cyclononadec-15-yl]-ureido}-3-methyl-pentanoic acid | CHEMBL409618
Type:
Small organic molecule
Emp. Form.:
C46H66N8O8
Mol. Mass.:
859.065
SMILES:
CC[C@H](C)[C@H](NC(=O)N[C@H]1CCCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(O)=O
Structure:
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