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Target
Low molecular weight protein-tyrosine phosphatase A
Ligand
BDBM50192337
Substrate
n/a
Meas. Tech.
ChEMBL_382597 (CHEMBL854512)
IC50
>100000±n/a nM
Citation
 Müller, D; Krick, A; Kehraus, S; Mehner, C; Hart, M; Küpper, FC; Saxena, K; Prinz, H; Schwalbe, H; Janning, P; Waldmann, H; König, GM Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity. J Med Chem 49:4871-8 (2006) [PubMed]  Article 
Target
Name:
Low molecular weight protein-tyrosine phosphatase A
Synonyms:
PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA
Type:
Hydrolase
Mol. Mass.:
17891.84
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
163
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
  
Inhibitor
Name:
BDBM50192337
Synonyms:
(2S,3S)-2-(3-{(3S,6R,9S,12S,15S)-3-benzyl-9-isobutyl-12-isopropyl-7-methyl-2,5,8,11,14-pentaoxo-6-[2-oxo-2-(2-ureido-phenyl)-ethyl]-1,4,7,10,13pentaaza-cyclononadec-15-yl}-ureido)-3-methyl-pentanoic acid | CHEMBL439324
Type:
Small organic molecule
Emp. Form.:
C45H65N9O10
Mol. Mass.:
892.0519
SMILES:
CC[C@H](C)[C@H](NC(=O)N[C@H]1CCCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)c2ccccc2NC(N)=O)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC1=O)C(C)C)C(O)=O
Structure:
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