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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50192427
Substrate
n/a
Meas. Tech.
ChEMBL_379936 (CHEMBL864856)
IC50
7000±n/a nM
Citation
 Palmer, BD; Thompson, AM; Booth, RJ; Dobrusin, EM; Kraker, AJ; Lee, HH; Lunney, EA; Mitchell, LH; Ortwine, DF; Smaill, JB; Swan, LM; Denny, WA 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem 49:4896-911 (2006) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50192427
Synonyms:
4-(2,6-dibromophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL378067
Type:
Small organic molecule
Emp. Form.:
C20H10Br2N2O3
Mol. Mass.:
486.113
SMILES:
Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Br)cccc1Br |(7.66,-44.93,;8.99,-45.7,;8.99,-47.24,;10.32,-48.02,;11.65,-47.25,;13.13,-47.72,;14.03,-46.47,;15.57,-46.31,;16.2,-44.9,;15.28,-43.65,;15.6,-42.15,;17.01,-41.53,;14.27,-41.38,;13.13,-42.4,;11.63,-42.08,;13.75,-43.81,;13.13,-45.22,;11.65,-45.69,;10.32,-44.93,;17.72,-44.74,;18.63,-45.98,;18.01,-47.39,;20.16,-45.82,;20.78,-44.41,;19.87,-43.16,;18.34,-43.33,;17.43,-42.09,)|
Structure:
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