Compile Data Set for Download or QSAR
maximum 50k data
Found 551 with Last Name = 'booth' and Initial = 'rj'
LigandPNGBDBM6302(8-cyclopentyl-6-acetyl-5-methyl-2-{[4-(piperazin-1...)
Affinity DataIC50:  2nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245691(9-hydroxy-6-(3-(methylamino)propyl)-4-phenylpyrrol...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232242(4-(2-chlorophenyl)-8-(3-(dimethylamino)propoxy)-9-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245342(4-(2-Chlorophenyl)-9-hydroxy-6-[2-hydroxy-3-(methy...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6386(8-Cyclopentyl-5-methyl-7-oxo-2-(4-piperazin-1-yl-p...)
Affinity DataIC50:  4nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374070(CHEMBL271084)
Affinity DataIC50:  4nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245693(4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-(methylamino...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6383(8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...)
Affinity DataIC50:  5nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  5nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245523(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6303(Pyrido-[2,3-d]-pyrimidin-7-one 37 | ethyl 8-cyclop...)
Affinity DataIC50:  6nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6358(8-Cyclopentyl-2-(4-piperazin-1-yl-phenylamino)-8H-...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6276(8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245387(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374063(CHEMBL270866)
Affinity DataIC50:  7nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245496(4-(2,6-Dichlorophenyl)-9-hydroxy-6-(3-hydroxypropy...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245457(4-(2,6-Dichlorophenyl)-9-hydroxy-6-(2-hydroxyethyl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245425(4-(2-Chlorophenyl)-9-hydroxy-6-[2-(1H-1,2,4-triazo...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245384(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6355(8-Cyclopentyl-2-(4-morpholin-4-yl-phenylamino)-8H-...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6356(8-Cyclopentyl-2-(4-piperidin-1-yl-phenylamino)-8H-...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232232(4-(2-chlorophenyl)-8-(3-(dimethylamino)propoxy)-9-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Cdc2 kinase PY15 phosphorylation in HT29 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374068(CHEMBL271071)
Affinity DataIC50:  10nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50192371(4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazol...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50192371(4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazol...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Wee1 in presence of 9.5 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245386(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245692(4-(2-chlorophenyl)-9-hydroxy-6-(3-(methylamino)pro...)
Affinity DataIC50:  12nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50192393(4-(2-chloro-3-hydroxyphenyl)-9-hydroxypyrrolo[3,4-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human Wee1 in presence of 9.5 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50192422(4-(2-iodophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human Wee1 in presence of 9.5 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245458(4-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245341(3-(4-(2,6-dichlorophenyl)-9-hydroxy-1,3-dioxo-2,3-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374067(CHEMBL255427)
Affinity DataIC50:  14nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM6276(8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...)
Affinity DataIC50:  14nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6352(2-Aminoquinazoline 31 | 8-cyclopentyl-5-methyl-2-{...)
Affinity DataIC50:  14nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374069(CHEMBL255565)
Affinity DataIC50:  14nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245525(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50192377(4-(2-chloro-6-methoxyphenyl)-9-hydroxypyrrolo[3,4-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Wee1 in presence of 9.5 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232227(4-(2-chlorophenyl)-9-hydroxy-6-(2-hydroxyethyl)-8-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374060(CHEMBL272267)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
LigandPNGBDBM6381(6-Chloro-8-cyclopentyl-5-methyl-2-(4-piperazin-1-y...)
Affinity DataIC50:  16nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245459(4-(2-Chlorophenyl)-9-hydroxy-6-[3-(1H-tetrazol-5-y...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50192428(9-hydroxy-4-(3-thienyl)pyrrolo[3,4-c]carbazole-1,3...)
Affinity DataIC50:  17nMAssay Description:Inhibition at human Chk1 in presence of 4 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374066(CHEMBL401776)
Affinity DataIC50:  18nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245497(9-Hydroxy-6-(3-hydroxypropyl)-4-(2-methoxyphenyl)-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6359(8-Cyclopentyl-5-methyl-2-[4-(4-methyl-piperazin-1-...)
Affinity DataIC50:  18nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50192382(4-(2,6-dichloro-3-hydroxyphenyl)-9-hydroxypyrrolo[...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human Wee1 in presence of 9.5 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245426(4-(2-Chlorophenyl)-9-hydroxy-6-[2-(1H-1,2,4-triazo...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50192402(4-(4-amino-2-methoxyphenyl)-9-hydroxypyrrolo[3,4-c...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human Wee1 in presence of 9.5 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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