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Target
Wee1-like protein kinase
Ligand
BDBM50192382
Substrate
n/a
Meas. Tech.
ChEMBL_379935 (CHEMBL864855)
IC50
18±n/a nM
Citation
 Palmer, BD; Thompson, AM; Booth, RJ; Dobrusin, EM; Kraker, AJ; Lee, HH; Lunney, EA; Mitchell, LH; Ortwine, DF; Smaill, JB; Swan, LM; Denny, WA 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem 49:4896-911 (2006) [PubMed]  Article 
Target
Name:
Wee1-like protein kinase
Synonyms:
Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:
PROTEIN
Mol. Mass.:
71599.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1445054
Residue:
646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
  
Inhibitor
Name:
BDBM50192382
Synonyms:
4-(2,6-dichloro-3-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL386048
Type:
Small organic molecule
Emp. Form.:
C20H10Cl2N2O4
Mol. Mass.:
413.21
SMILES:
Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)ccc(O)c1Cl |(-8.42,-23.21,;-7.09,-23.98,;-7.09,-25.52,;-5.76,-26.29,;-4.43,-25.52,;-2.95,-26,;-2.05,-24.75,;-.51,-24.59,;.12,-23.18,;-.8,-21.93,;-.48,-20.43,;.93,-19.81,;-1.81,-19.66,;-2.95,-20.68,;-4.45,-20.36,;-2.33,-22.09,;-2.95,-23.49,;-4.43,-23.97,;-5.76,-23.21,;1.64,-23.01,;2.26,-21.61,;1.35,-20.37,;3.79,-21.44,;4.7,-22.69,;4.08,-24.1,;4.99,-25.34,;2.55,-24.26,;1.93,-25.67,)|
Structure:
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