Reaction Details Report a problem with these data
Target
NAD-dependent protein deacylase sirtuin-6
Ligand
BDBM50147581
Substrate
n/a
Meas. Tech.
ChEMBL_2268097
EC50
246000±n/a nM
Citation
 Fiorentino, F; Mai, A; Rotili, D Emerging Therapeutic Potential of SIRT6 Modulators. J Med Chem 64:9732-9758 (2021) [PubMed] 
Target
Name:
NAD-dependent protein deacylase sirtuin-6
Synonyms:
NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6)
Type:
Protein
Mol. Mass.:
39133.03
Organism:
Homo sapiens (Human)
Description:
Q8N6T7
Residue:
355
Sequence:
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
  
Inhibitor
Name:
BDBM50147581
Synonyms:
1-tridecanecarboxylic acid | 14:0 | CH3-[CH2]12-COOH | CHEMBL111077 | Myristinsaeure | acide tetradecanoique | myristic acid | n-Tetradecan-1-oic acid | n-Tetradecoic acid | n-tetradecanoic acid | tetradecoic acid
Type:
Small organic molecule
Emp. Form.:
C14H28O2
Mol. Mass.:
228.3709
SMILES:
CCCCCCCCCCCCCC(O)=O
Structure:
Search PDB for entries with ligand similarity: