Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 2
Ligand
BDBM50193608
Substrate
n/a
Meas. Tech.
ChEMBL_420723 (CHEMBL856564)
IC50
960±n/a nM
Citation
 Jiang, J; Lin, P; Hoang, M; Chang, L; Tan, C; Feighner, S; Palyha, OC; Hreniuk, DL; Pan, J; Sailer, AW; Morin, NR; MacNeil, DJ; Howard, AD; Van der Ploeg, LH; Goulet, MT; DeVita, RJ 4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists. Bioorg Med Chem Lett 16:5275-9 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 2
Synonyms:
GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38862.16
Organism:
Homo sapiens (Human)
Description:
Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1
Residue:
340
Sequence:
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
  
Inhibitor
Name:
BDBM50193608
Synonyms:
(E)-N-(4-(cyclobutylamino)-2-propylquinolin-6-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide | CHEMBL217480
Type:
Small organic molecule
Emp. Form.:
C26H26F3N3O
Mol. Mass.:
453.4993
SMILES:
CCCc1cc(NC2CCC2)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Structure:
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