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Target
Guanine deaminase
Ligand
BDBM50193756
Substrate
n/a
Meas. Tech.
ChEMBL_424083 (CHEMBL855086)
Ki
53600±n/a nM
Citation
 Ujjinamatada, RK; Bhan, A; Hosmane, RS Design of inhibitors against guanase: synthesis and biochemical evaluation of analogues of azepinomycin. Bioorg Med Chem Lett 16:5551-4 (2006) [PubMed]  Article 
Target
Name:
Guanine deaminase
Synonyms:
GAH | GDA | GUAD_HUMAN | Guanase | Guanine aminase | Guanine aminohydrolase | KIAA1258 | p51-nedasin
Type:
PROTEIN
Mol. Mass.:
50993.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_885179
Residue:
454
Sequence:
MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV
  
Inhibitor
Name:
BDBM50193756
Synonyms:
4,5,7,8-tetrahydro-6-hydroxymethyl-6H-imidazo[4,5-e][1,4]diazepine-5,8-dione | CHEMBL220699
Type:
Small organic molecule
Emp. Form.:
C7H8N4O3
Mol. Mass.:
196.1634
SMILES:
OCC1NC(=O)c2[nH]cnc2NC1=O
Structure:
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