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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50193794
Substrate
n/a
Meas. Tech.
ChEMBL_424101 (CHEMBL856747)
IC50
832±n/a nM
Citation
 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Discovery of orally active butyrolactam 11beta-HSD1 inhibitors. Bioorg Med Chem Lett 16:5555-60 (2006) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50193794
Synonyms:
3-benzyl-1-(5-hydroxy-adamantan-2-yl)-pyrrolidin-2-one | CHEMBL376306
Type:
Small organic molecule
Emp. Form.:
C21H27NO2
Mol. Mass.:
325.4446
SMILES:
O[C@@]12CC3CC(C1)[C@@H](C(C3)C2)N1CCC(Cc2ccccc2)C1=O |wU:7.13,wD:1.0,TLB:4:3:10:6.5.7,4:5:2.3.9:10,THB:7:5:2:9.8.10,7:8:2:6.4.5,11:7:2.3.9:10,(16.16,6.86,;16.17,5.31,;14.75,5.95,;15.69,4.73,;15.75,3.19,;17.28,2.6,;16.29,3.78,;18.6,3.19,;18.6,4.72,;17.14,5.26,;17.61,5.91,;19.93,2.42,;20.46,.99,;22,1.05,;22.42,2.51,;23.78,3.21,;25.07,2.37,;24.99,.83,;26.28,-0,;27.66,.72,;27.74,2.23,;26.44,3.08,;21.13,3.38,;21.13,4.99,)|
Structure:
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