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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50193797
Substrate
n/a
Meas. Tech.
ChEMBL_424101 (CHEMBL856747)
IC50
35±n/a nM
Citation
 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Discovery of orally active butyrolactam 11beta-HSD1 inhibitors. Bioorg Med Chem Lett 16:5555-60 (2006) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50193797
Synonyms:
4-(3-benzyl-2-oxo-pyrrolidin-1-yl)-adamantane-1-carboxylic acid amide | CHEMBL221132
Type:
Small organic molecule
Emp. Form.:
C22H28N2O2
Mol. Mass.:
352.4699
SMILES:
NC(=O)[C@@]12CC3CC(C1)[C@@H](C(C3)C2)N1CCC(Cc2ccccc2)C1=O |wU:9.15,wD:3.2,TLB:6:5:12:8.7.9,6:7:4.5.11:12,THB:9:7:4:11.10.12,9:10:4:8.6.7,13:9:4.5.11:12,(-8.33,-4.6,;-6.99,-5.36,;-5.65,-4.58,;-6.98,-6.91,;-8.4,-6.28,;-7.46,-7.49,;-7.4,-9.03,;-5.87,-9.62,;-6.86,-8.44,;-4.55,-9.03,;-4.55,-7.5,;-6.01,-6.97,;-5.54,-6.32,;-3.22,-9.8,;-2.69,-11.24,;-1.14,-11.17,;-.73,-9.71,;.64,-9.01,;1.92,-9.85,;1.84,-11.4,;3.14,-12.23,;4.52,-11.51,;4.59,-9.99,;3.29,-9.15,;-2.02,-8.84,;-2.02,-7.23,)|
Structure:
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