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Target
Sentrin-specific protease 3
Ligand
BDBM103830
Substrate
n/a
Meas. Tech.
ChEMBL_2269409
IC50
4600±n/a nM
Citation
 Wei, J; Wang, H; Zheng, Q; Zhang, J; Chen, Z; Wang, J; Ouyang, L; Wang, Y Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers. Eur J Med Chem 241:0 (2022) [PubMed] 
Target
Name:
Sentrin-specific protease 3
Synonyms:
3.4.22.- | SENP3 | SUMO-1-specific protease 3 | Sentrin-specific protease 3 | Sentrin/SUMO-specific protease SENP3
Type:
PROTEIN
Mol. Mass.:
65025.20
Organism:
Homo sapiens
Description:
ChEMBL_120935
Residue:
574
Sequence:
MKETIQGTGSWGPEPPGPGIPPAYSSPRRERLRWPPPPKPRLKSGGGFGPDPGSGTTVPARRLPVPRPSFDASASEEEEEEEEEEDEDEEEEVAAWRLPPRWSQLGTSQRPRPSRPTHRKTCSQRRRRAMRAFRMLLYSKSTSLTFHWKLWGRHRGRRRGLAHPKNHLSPQQGGATPQVPSPCCRFDSPRGPPPPRLGLLGALMAEDGVRGSPPVPSGPPMEEDGLRWTPKSPLDPDSGLLSCTLPNGFGGQSGPEGERSLAPPDASILISNVCSIGDHVAQELFQGSDLGMAEEAERPGEKAGQHSPLREEHVTCVQSILDEFLQTYGSLIPLSTDEVVEKLEDIFQQEFSTPSRKGLVLQLIQSYQRMPGNAMVRGFRVAYKRHVLTMDDLGTLYGQNWLNDQVMNMYGDLVMDTVPEKVHFFNSFFYDKLRTKGYDGVKRWTKNVDIFNKELLLIPIHLEVHWSLISVDVRRRTITYFDSQRTLNRRCPKHIAKYLQAEAVKKDRLDFHQGWKGYFKMNVARQNNDSDCGAFVLQYCKHLALSQPFSFTQQDMPKLRRQIYKELCHCKLTV
  
Inhibitor
Name:
BDBM103830
Synonyms:
SPI-05 | US11041859, Code SPI-05 | US9791447, Compound SPI-05
Type:
Small organic molecule
Emp. Form.:
C34H26N6O6S2
Mol. Mass.:
678.737
SMILES:
Nc1ccc(\N=N\c2ccc(\C=C\c3ccc(cc3S(O)(=O)=O)\N=N\c3ccc(N)c4ccccc34)c(c2)S(O)(=O)=O)c2ccccc12
Structure:
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