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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50194360
Substrate
n/a
Meas. Tech.
ChEMBL_422109 (CHEMBL907685)
IC50
21±n/a nM
Citation
 Fluxe, A; Wu, S; Sheffer, JB; Janusz, JM; Murawsky, M; Fadayel, GM; Fang, B; Hare, M; Djandjighian, L Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers. Bioorg Med Chem Lett 16:5855-8 (2006) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50194360
Synonyms:
(E)-thyl-1-methyl-6,7-dihydro-1H-indol-4(5H)-one O-phenylcarbamoyl oxime | CHEMBL216281
Type:
Small organic molecule
Emp. Form.:
C20H25N3O2
Mol. Mass.:
339.4314
SMILES:
CCc1c(CC)n(C)c2CCCC(=NOC(=O)Nc3ccccc3)c12 |w:13.13|
Structure:
Search PDB for entries with ligand similarity: