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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50195712
Substrate
n/a
Meas. Tech.
ChEMBL_425034 (CHEMBL912555)
IC50
4962±n/a nM
Citation
 Warshawsky, AM; Alt, CA; Brozinick, JT; Harkness, AR; Hawkins, ED; Henry, JR; Matthews, DP; Miller, AR; Misener, EA; Montrose-Rafizadeh, C; Rhodes, GA; Shen, Q; Vance, JA; Udodong, UE; Wang, M; Zhang, TY; Zink, RW Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands. Bioorg Med Chem Lett 16:6328-33 (2006) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50195712
Synonyms:
3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((3-phenylpropanamido)methyl)phenyl)propanoic acid | CHEMBL223349
Type:
Small organic molecule
Emp. Form.:
C31H32N2O5
Mol. Mass.:
512.5962
SMILES:
Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)CCc2ccccc2)c1)-c1ccccc1
Structure:
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