Affinity DataKi: 0.0700nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
Affinity DataKi: 0.450nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 6.70nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 8.20nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
Affinity DataKi: 45nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 58nMAssay Description:Binding affinity to human EP4More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 102nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 126nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
Affinity DataKi: 129nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
Affinity DataKi: 261nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
Affinity DataKi: 372nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
Affinity DataKi: 448nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 449nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
Affinity DataKi: 512nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.21E+3nMAssay Description:Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.80E+3nMAssay Description:Antagonist activity at human EP2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.27E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP3 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >1.27E+4nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
Affinity DataKi: >1.40E+4nMAssay Description:Binding affinity to human EP3More data for this Ligand-Target Pair
Affinity DataKi: >1.40E+4nMAssay Description:Binding affinity to human EP3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.74E+4nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
Affinity DataKi: >1.75E+4nMAssay Description:Binding affinity to human EP1More data for this Ligand-Target Pair
Affinity DataKi: >1.75E+4nMAssay Description:Antagonist activity at human EP3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.75E+4nMAssay Description:Binding affinity to human EP1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.75E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP1 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >1.89E+4nMAssay Description:Binding affinity to human EP2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.89E+4nMAssay Description:Binding affinity to human EP2More data for this Ligand-Target Pair
Affinity DataKi: >1.92E+4nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.95E+4nMAssay Description:Antagonist activity at human EP1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assa...More data for this Ligand-Target Pair
Affinity DataIC50: 0.670nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assa...More data for this Ligand-Target Pair