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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50195708
Substrate
n/a
Meas. Tech.
ChEMBL_425034 (CHEMBL912555)
IC50
1495±n/a nM
Citation
 Warshawsky, AM; Alt, CA; Brozinick, JT; Harkness, AR; Hawkins, ED; Henry, JR; Matthews, DP; Miller, AR; Misener, EA; Montrose-Rafizadeh, C; Rhodes, GA; Shen, Q; Vance, JA; Udodong, UE; Wang, M; Zhang, TY; Zink, RW Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands. Bioorg Med Chem Lett 16:6328-33 (2006) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50195708
Synonyms:
3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2-morpholinothiazol-4-yl)ethoxy)phenyl)propanoic acid | CHEMBL223351
Type:
Small organic molecule
Emp. Form.:
C24H33N3O6S
Mol. Mass.:
491.6
SMILES:
CC(C)OC(=O)NCc1cc(OCCc2nc(sc2C)N2CCOCC2)ccc1CCC(O)=O
Structure:
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