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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50195805
Substrate
n/a
Meas. Tech.
ChEMBL_421994 (CHEMBL907083)
IC50
480±n/a nM
Citation
 Wu, S; Fluxe, A; Sheffer, J; Janusz, JM; Blass, BE; White, R; Jackson, C; Hedges, R; Murawsky, M; Fang, B; Fadayel, GM; Hare, M; Djandjighian, L Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers. Bioorg Med Chem Lett 16:6213-8 (2006) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50195805
Synonyms:
1-[1-(4-methylphenyl)cyclopropyl]-2-(3-phenylpropyl)-2H-1,2,3,4,5-pentazol-1-ylium | CHEMBL217482
Type:
Small organic molecule
Emp. Form.:
C19H22N5
Mol. Mass.:
320.4109
SMILES:
Cc1ccc(cc1)C1(CC1)[n+]1nnnn1CCCc1ccccc1
Structure:
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