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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50197439
Substrate
n/a
Meas. Tech.
ChEMBL_432257 (CHEMBL914035)
IC50
13±n/a nM
Citation
 Pham-Huu, DP; Deschamps, JR; Liu, S; Madras, BK; Meltzer, PC Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Bioorg Med Chem 15:1067-82 (2006) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
SC6A4_MACMU | SLC6A4 | Serotonin transporter
Type:
PROTEIN
Mol. Mass.:
70256.94
Organism:
Macaca mulatta
Description:
ChEMBL_432257
Residue:
630
Sequence:
METTPLNSQKQLSACKDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPAATTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSFVCIPTYIAYRLISTPGTFKERIIKSITPETPTEIPCGDVRLNAV
  
Inhibitor
Name:
BDBM50197439
Synonyms:
2-beta-carbomethoxy-3-beta-(2-naphthyl)-8-thiabicyclo[3.2.1]octane | CHEMBL387983
Type:
Small organic molecule
Emp. Form.:
C19H20O2S
Mol. Mass.:
312.426
SMILES:
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc3ccccc3c1)S2 |TLB:11:10:21:6.7,THB:2:4:21:6.7|
Structure:
Search PDB for entries with ligand similarity: