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Target
Type-2 angiotensin II receptor
Ligand
BDBM50199319
Substrate
n/a
Meas. Tech.
ChEMBL_411307 (CHEMBL907245)
Ki
>10000±n/a nM
Citation
 Wu, X; Wan, Y; Mahalingam, AK; Murugaiah, AM; Plouffe, B; Botros, M; Karlén, A; Hallberg, M; Gallo-Payet, N; Alterman, M Selective angiotensin II AT2 receptor agonists: arylbenzylimidazole structure-activity relationships. J Med Chem 49:7160-8 (2006) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50199319
Synonyms:
CHEMBL217084 | N-(4,4,4-triflouro-butyloxycarbonyl)-3-(4-imidazol-1-ylmethylphenyl)-5-isobutylthiophene-2-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H26F3N3O4S2
Mol. Mass.:
529.595
SMILES:
CC(C)Cc1cc(c(s1)S(=O)(=O)NC(=O)OCCCC(F)(F)F)-c1ccc(Cn2ccnc2)cc1
Structure:
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