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Target
Mu-type opioid receptor
Ligand
BDBM50206644
Substrate
n/a
Meas. Tech.
ChEMBL_438449 (CHEMBL887549)
Ki
990±n/a nM
Citation
 Lee, YS; Nyberg, J; Moye, S; Agnes, RS; Davis, P; Ma, SW; Lai, J; Porreca, F; Vardanyan, R; Hruby, VJ Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorg Med Chem Lett 17:2161-5 (2007) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | Opiate non-selective | Opioid receptor B | OPRM_RAT | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rat
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50206644
Synonyms:
N-(1-(3-amino-3-(4-chlorophenyl)propanoyl)piperidin-4-yl)-N-phenylpropionamide | CHEMBL395545
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCC(=O)N(C1CCN(CC1)C(=O)CC(N)c1ccc(Cl)cc1)c1ccccc1 |w:14.15|
Structure:
Search PDB for entries with ligand similarity: