Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM50055371
Substrate
n/a
Meas. Tech.
ChEMBL_428853 (CHEMBL917129)
IC50
3300±n/a nM
Citation
 Touaibia, M; Djimdé, A; Cao, F; Boilard, E; Bezzine, S; Lambeau, G; Redeuilh, C; Lamouri, A; Massicot, F; Chau, F; Dong, CZ; Heymans, F Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities. J Med Chem 50:1618-26 (2007) [PubMed]  Article 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM50055371
Synonyms:
(3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-indol-4-yloxy)-acetic acid | CHEMBL357979
Type:
Small organic molecule
Emp. Form.:
C26H22N2O5
Mol. Mass.:
442.4633
SMILES:
Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1-c1ccccc1
Structure:
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