Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50210122
Substrate
n/a
Meas. Tech.
ChEMBL_443952 (CHEMBL893117)
Ki
2250±n/a nM
Citation
 Paillet-Loilier, M; Fabis, F; Lepailleur, A; Bureau, R; Butt-Gueulle, S; Dauphin, F; Lesnard, A; Delarue, C; Vaudry, H; Rault, S Novel aminoethylbiphenyls as 5-HT7 receptor ligands. Bioorg Med Chem Lett 17:3018-22 (2007) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50210122
Synonyms:
CHEMBL234881 | [2-(2',6'-dimethyl-biphenyl-3-yl)-ethyl]-dimethyl-amine
Type:
Small organic molecule
Emp. Form.:
C18H23N
Mol. Mass.:
253.3819
SMILES:
CN(C)CCc1cccc(c1)-c1c(C)cccc1C
Structure:
Search PDB for entries with ligand similarity: