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Target
Macrophage inflammatory protein-1 alpha receptor
Ligand
BDBM50210976
Substrate
n/a
Meas. Tech.
ChEMBL_444185 (CHEMBL892293)
IC50
130±n/a nM
Citation
 Xie, YF; Lake, K; Ligsay, K; Komandla, M; Sircar, I; Nagarajan, G; Li, J; Xu, K; Parise, J; Schneider, L; Huang, D; Liu, J; Dines, K; Sakurai, N; Barbosa, M; Jack, R Structure-activity relationships of novel, highly potent, selective, and orally active CCR1 antagonists. Bioorg Med Chem Lett 17:3367-72 (2007) [PubMed]  Article 
Target
Name:
Macrophage inflammatory protein-1 alpha receptor
Synonyms:
C-C chemokine receptor type 1
Type:
PROTEIN
Mol. Mass.:
40846.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1281523
Residue:
355
Sequence:
MEISNITETYPTTTEYDYGDSTPCQKTDVRAFGAGLLPPLYSFVFIIGVVGNILVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDNWVFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFSLRARTVTFGIITSIIIWALAILASIPALCFFKAQWEFTHHTCSPHFPDESLKTWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPNEKKAKAVRLIFAITLLFFLLWTPYNLTVFVSAFQDVLFTNQCEQSKQLDLAIQVTEVIAYTHCCVNPIIYVFVGERFRKYLRQLFQRHVAIPLAKWLPFFSVDQLERTSSLTPSTGEHELSGGF
  
Inhibitor
Name:
BDBM50210976
Synonyms:
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(pyridin-3-ylmethylamino)cyclobut-3-ene-1,2-dione | CHEMBL397910
Type:
Small organic molecule
Emp. Form.:
C30H29ClFN5O4
Mol. Mass.:
578.034
SMILES:
C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O
Structure:
Search PDB for entries with ligand similarity: