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Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50212264
Substrate
n/a
Meas. Tech.
ChEMBL_455695 (CHEMBL886478)
EC50
61.2±n/a nM
Citation
 Lagu, B; Pio, B; Lebedev, R; Yang, M; Pelton, PD RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia. Bioorg Med Chem Lett 17:3497-503 (2007) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM50212264
Synonyms:
3-(3-(4-ethyl-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-4-(trifluoromethoxy)phenyl)but-2-enoic acid | CHEMBL248191
Type:
Small organic molecule
Emp. Form.:
C24H24F3NO5
Mol. Mass.:
463.4463
SMILES:
CCN1C(=O)C(C)(C)Oc2cc(C)c(cc12)-c1cc(ccc1OC(F)(F)F)C(\C)=C\C(O)=O
Structure:
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