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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50216931
Substrate
n/a
Meas. Tech.
ChEMBL_448530 (CHEMBL897679)
Ki
12±n/a nM
Citation
 Sutin, L; Andersson, S; Bergquist, L; Castro, VM; Danielsson, E; James, S; Henriksson, M; Johansson, L; Kaiser, C; Flyrén, K; Williams, M Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett 17:4837-40 (2007) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50216931
Synonyms:
2-(2-adamantylamino)-5,5-diethyl-1,3-oxazol-4(5H)-one | CHEMBL415260
Type:
Small organic molecule
Emp. Form.:
C17H26N2O2
Mol. Mass.:
290.4005
SMILES:
CCC1(CC)OC(NC2C3CC4CC(C3)CC2C4)=NC1=O |c:20,TLB:14:13:17:10.9.8,14:9:12.13.15:17,THB:8:9:12:15.16.17,8:16:12:10.14.9,7:8:12.13.15:17,(30.39,-21.27,;29.73,-19.88,;28.2,-19.75,;27.53,-21.14,;26,-21.26,;26.67,-19.52,;26.45,-18.06,;25.12,-17.29,;23.85,-18.17,;23.84,-19.69,;22.44,-20.04,;21.11,-19.55,;19.92,-20.83,;21.42,-20.41,;22.83,-20.98,;21.41,-18.82,;22.46,-17.58,;21.11,-18.06,;27.79,-17.28,;28.89,-18.38,;30.41,-18.12,)|
Structure:
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